A Quantitative Measurement of the Human Somatic Mutation Rate
نویسندگان
چکیده
منابع مشابه
A quantitative measurement of the human somatic mutation rate.
The mutation rate (mu) is a key biological feature of somatic cells that determines risk for malignant transformation, and it has been exceedingly difficult to measure in human cells. For this purpose, a potential sentinel is the X-linked PIG-A gene, because its inactivation causes lack of glycosylphosphatidylinositol-linked membrane proteins. We previously found that the frequency (f) of PIG-A...
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TABLE OF CONTENTS TEE PROBLEM The failure of attempts to produce gene variation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . The need for a means of measuring mutation rate . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Lethals as a practicable index of mutation rate . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . L Temperature as ...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2005
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-04-1198